Lime is involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. It couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilisation or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules [, ].
