TRAPPC14 (also known as MAP11) is a microtubule associated protein that regulates preciliary trafficking of Rabin8 (a guanine nucleotide exchange factor for Rab8) and ciliogenesis []. It is a specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether [, , ]. TRAPPC14 is dispensable for TRAPPII complex integrity but mediates Rabin8 association with the TRAPPII complex []. It also modulates YAP1 activity as transcriptional regulator []. Mutations in the MAP11 gene cause microcephaly in humans and zebrafish [].
