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Search results 1 to 1 out of 1 for Mkrn1

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: This domain is found at the C terminus of makorins, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs []. Makorin-1 (MKRN1) plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT []. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21 []. The exact function of the C-terminal region has not been determined.