Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix (ECM) and process a number of bioactive molecules. Matrix metalloproteinase-23 (MMP-23; MEROPS identifier M10.022) is a protease that may regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum []. MMP-23 is predominantly expressed in reproductive tissues [, ].