MTSS2 (also known as MTSS1-like protein, MTSS1L, or ABBA) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature []. MTSS2 contains an additional C-terminal WH2 domain that binds G-actin [].MTSS2 is a regulator of actin and plasma membrane dynamics in radial glial cells []. It binds the small GTPase Rac1 through its I-BAR domain and promotes PDGF-mediated membrane ruffling by activating Rac1 [].
This entry represents a subgroup of I-BAR (Bin/amphipysin/Rvs) domain-containing proteins, including MIM (MTSS1) and MTSS2 (also known as ABBA or MTSS1-like). BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature []. Most I-BAR proteins, including MIM and MTSS2, have an additional C-terminal WH2 domain, which binds G-actin [, , ].
