Microtubule-associated tumor suppressor candidate 2 (MTUS2, also known as TIP150) binds to end-binding protein 1 (EB1) and to mitotic centromere-associated kinesin (MCAK), an microtubule (MT) depolymerase that localizes to the plus end of MTs []. It facilitates the loading of MCAK onto the microtubule plus ends and orchestrates microtubule plus-end dynamics during cell division [].
