Matrix remodeling-associated protein 8 (MXRA8), also known as Limitrin or DICAM, is a type I transmembrane protein with two V-type Ig domains in the extracellular region and a short cytoplasmic tail []. It is involved in cell-cell adhesion through a heterophilic interaction with alphaVbeta3 integrin []and acts as a negative regulator of osteoclast differentiation by suppressing the integrin alphaVbeta3 pathway []. It also positively regulates primary cilia and Indian hedgehog signaling, resulting in elongation of long bone []. It has been shown to be a receptor for multiple arthritogenic alphaviruses [].
