This domain is found in eukaryotes, is approximately 70 amino acids in length, and contains a conserved CSD sequence motif. It is found in association with , . This domain is found in Myogenic factor 5 (Myf5) and Myoblast determination protein 1 (MyoD1). Myf5 is responsible for directing cells to the skeletal myocyte lineage during development []. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function [].
Myogenic factors are involved in muscle differentiation, inducing fibroblasts to differentiate into myoblasts. Myogenic factor 5 (Myf5) is responsible for directing cells to the skeletal myocyte lineage during development []. Myf5 and Myod (myoblast determination protein 1) are predominantly expressed in proliferating myoblasts while Myf4 and Myf6 are involved in differentiation of myotubes []. Myogenin (MYOG) is a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy [, ].
