Myogenic factors are involved in muscle differentiation, inducing fibroblasts to differentiate into myoblasts. Myogenic factor 5 (Myf5) is responsible for directing cells to the skeletal myocyte lineage during development []. Myf5 and Myod (myoblast determination protein 1) are predominantly expressed in proliferating myoblasts while Myf4 and Myf6 are involved in differentiation of myotubes []. Myogenin (MYOG) is a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy [, ].
