This entry represents the N-terminal domain of acid ceramidase (AC), which degrades ceramide into sphingosine and fatty acid [], and N-acylethanolamine-hydrolysing acid amidase (NAAA). NAAA is an N-acylethanolamine-hydrolysing enzyme that shows structural and functional similarity to acid ceramidase []. AC and NAAA can be cleaved into two chains: alpha and beta [, ]. This entry represent the beta subunit (chain).
This domain can be found in several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides. These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) (), penicillin acylase () and acid ceramidase (). This domain is also found at the C terminus of acid ceramidase (AC) and N-acylethanolamine-hydrolysing acid amidase (NAAA) []. AC and NAAA can be cleaved into two chains: alpha and beta. This domain represent the alpha subunit (chain).
