The Nucleobase Cation Symporter-1 (NCS1) family are H+/Na+ symporters specific for the uptake of purines, pyrimidines and related metabolites (http://www.tcdb.org/search/result.php?tc=2.A.39). This entry consists of bacterial and yeast transporters of the NCS1 family. Members of this family possess twelve putative transmembrane α-helical spanners (TMSs).