NDNF (neuron-derived neurotrophic factor) is a glycosylated, disulfide-bonded secretory protein that contains fibronectin type III domains and two predicted N-linked glycosylation sites [, ]. It is expressed in brain and spinal cord that promotes migration and neurite growth. It acts as a modulator that promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms [].
This is the C-terminal domain of protein NDNF (Neuron-derived Neurotrophic Factor). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains one of the two fibronectin type III domains (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation [, ].
