NDOR1, also known as Tah18 in budding yeast, is a conserved NAPDH-dependent diflavin reductase from eukaryotes. It is a component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery and part of an electron transfer chain functioning in an early step of cytosolic Fe/S biogenesis. It transfers electrons from NADPH to the Fe/S cluster DRE2 in budding yeasts or CIAPIN1 in humans [, ].
This entry includes flavodoxins and flavodoxin-like proteins, such as NADPH-dependent diflavin oxidoreductase NDOR1 and nitric oxide synthases. Flavodoxins act in various electron-transport systems as functionalanalogues of ferredoxins []. Although flavodoxins are found only in certain bacteria and algae []the proteins share similarity with a number of protein domains of both prokaryotic and eukaryotic origin [].
