Neuroligin-2 (NLGN2) belongs to the neuroligins (NLGNs) family, whose members interact with the neurexin family members and are involved in the modulation of synaptic transmission []. NLGN2 is a postsynaptic cell adhesion protein that is predominantly expressed at inhibitory synapses and required for synapse specification and stabilisation []. Its structure has been solved [].