Neuroligin-3 (NLGN3) belongs to the neuroligins (NLGNs) family, whose members interact with the neurexin family members and are involved in the modulation of synaptic transmission []. NLGN3 is a neuronal adhesion protein at both inhibitory GABAergic synapses and excitatory (glutamatergic) synapses []. Mutations in neuroligin 3 genes have been found in autism [].
Neuroligins (NLGNs) interact with the neurexin family members and are involved in the modulation of synaptic transmission []. Mammals have four Nlgn proteins, with the Nlgn3 and Nlgn4 gene in humans localised to the X-chromosome. In humans, the Nlgn4 gene is complemented on the Y-chromosome by a similar Nlgn5 gene [].
