This entry includes a group of pre-RNA processing ribonucleoproteins (RNPs), including Nop56/Nop58 from animals and their homologue, Nop5, from archaea. Proteins in this family contains the Nop domain, which is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively α-helical [, ]. Nop56 and Nop58 are components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles [, ].
This N-terminal domain is found in Nucleolar protein 58/56 from fungi and animals and the homologues form plants. These are RNA-binding proteins of the NOP5 family []. Nop56 and Nop58 are components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles [, ]. This domain interacts with Nop1 and forms the box B/C side, in the case of Nop56, or box C'/D side in the case of Nop58, of U3 snoRNP [].
