NudC-like 2/NudC domain-containing protein 2 (NudCL2/NUDCD2) regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. LIS1 is a key regulator of cytoplasmic dynein, and is critical for cell proliferation, survival, and neuronal migration []. Like other members of the NudC family, NUDCD2 has a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of Hsp90 [, ]. This entry represents the p23 domain of NUDCD2.
