This entry represents Oxidized purine nucleoside triphosphate hydrolase (8ODP, also known as 7,8-dihydro-8-oxoguanine triphosphatase and MHT1), and similar Nudix hydrolase domain-containing proteins from bacteria, eukaryots and archaea. This protein has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP and catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA [, , ]. It was originally considered to play an important role as sanitizer of the oxidized nucleotide pool [, ]. However, later studies indicate that NUDT1 plays a redundant role in eliminating oxidized nucleotides and that it is not essential for cancer cell proliferation and survival [, ].
