Neurexophilins (Nxphs) comprise a family of glycoproteins (Nxph1-4) that exhibit characteristics of secreted, preproprotein-derived molecules []. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins [].Nxph1 plays an instructive role in synaptic short-term plasticity and the configuration with GABA receptors []. Nxph3 has been shown to support the survival of mouse induced pluripotent stem cell-derived (iPSC-derived) dopaminergic (DA) neurons in vitro and in vivo [].
