Proteins of this family have been identified in a number of species as a nuclear protein with a cell cycle dependence. Various names have been given to members of this family which include cell cycle protein p38-2G4, also known as proliferation-associated protein PA2G4 [, ], curved DNA-binding protein [], proliferation-associated protein A, and ErbB3-binding protein 1 (Ebp1) []. They constitute the proliferation-associated PA2G4 family, which is structurally homologous to the type II methionine aminopeptidases, but without methionine aminopeptidase activity [, ]. ErbB3 binding protein-1 (Ebp1) is a potential regulator of ErbB3 signaling, and is implicated in cell growth, apoptosis and differentiation in many cell types [, ].These proteins are classified as non-peptidase homologues in the MEROPS peptidase family M24 (clan MG).
