PBXIP1/HPIP is a co-repressor of pre-B-cell leukemia homeobox 1 (PBX1) []and is also known to regulate estrogen receptor functions by associating with the microtubule network. HPIP is associated with microtubules through a leucine-rich domain and can tether estrogen receptor alpha (ERalpha) to microtubules, which allows them to influence ERalpha signalling [, , ]. It also plays an important role in erythroid differentiation by modulating the PI3K/AKT pathway []. It has been shown to play a role in cancer development and progression [].
