This entry includes the HTH-type transcriptional regulator RamB (Rv0465c/MT0481) and PrpR. In Corynebacterium glutamicum RamB controls the expression of several genes involved in acetate metabolism []. In Mycobacterium tuberculosis RamB is involved in the control of the glyoxylate cycle []and its paralogue PrpR in the regulation of the methylcitrate pathway []. Family members contain a helix-turn-helix (HTH) motif, which is a major structural motif capable of binding DNA. Many proteins with this motif have been shown to regulate gene expression.This entry also includes RSP_2186 (also known as PccR) from Rhodobacter sphaeroides. RSP_2186 is a transcriptional regulator that controls pccB expression, and consequently, PCC (propionyl-CoA carboxylase) activity [].
