Pex26 is a type II peroxisomal membrane protein that recruits Pex6-Pex1 complexes to peroxisomes []. Mutations in the Pex26 gene cause peroxisome biogenesis disorder complementation group 8 (PBD-CG8) and peroxisome biogenesis disorder 7A/B (PBD7A/B) [].
Several peroxisome biogenesis factors, termed peroxins (PEXs), are involved in the transport of peroxisomal proteins from the cytosol to peroxisomes. ABERRANT PEROXISOME MORPHOLOGY9 (APEM9) is involved in peroxisomal protein transport through its recruitment of the AAA ATPase complex PEX1-PEX6 to peroxisomal membranes via protein-protein interactions with PEX6 []. APEM9 has a similar function in plants to mammalian Pex26 and yeast Pex15p, although the amino acid conservation among them is very low. APEM9 plays critical roles in peroxisome biogenesis and function, which is essential for jasmonic acid production and pollen maturation and germination [].
