This entry includes protein germ cell-less (Gcl) from Drosophila melanogaster and related proteins, such as GMCL1 and GMCL2 from mammals. Gcl is required for germline formation [, ]. It promotes PGC (Primordial Germ Cells) fate by mediating degradation of Torso, a receptor tyrosine kinase (RTK) and major determinant of somatic cell fate [].