PPLPPR4, also known as plasticity-related gene 1 protein (PRG-1), was originally identified as a 2-lysophosphatidate/LPA phosphatase []. Later its activity is questioned []. PPLPPR4 facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus [].
