Protein phosphatase 1 regulatory subunit 12C (PPP1R12C, also known as p85) is a myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) substrate. It is associated with protein phosphatase 1delta (PP1delta) through its N terminus. This association is required for the regulation of both the catalytic activities and the assembly of actin cytoskeleton. Its C terminus is involved in dimerisation and interaction with other proteins [].