| Description: |
This entry represents the second PTP domain of Receptor-type tyrosine-protein phosphatase A.Receptor-type tyrosine-protein phosphatase A (PTPRA), also known as receptor-type tyrosine-protein phosphatase alpha (R-PTP-alpha), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs () catalyse the dephosphorylation of phosphotyrosine peptides. PTPRA is a positive regulator of Src and Src family kinases via dephosphorylation of the Src-inhibitory tyrosine 527 [, ]. Thus, it affects transformation and tumourigenesis, inhibition of proliferation, cell cycle arrest, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity [, , , , , , , , , , , , , , , , , , ]. It is also involved in interleukin-1 signalling in fibroblasts through its interaction with the focal adhesion targeting domain of focal adhesion kinase [, , ]. PTPRA comprises a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem PTP domains. |
