This SPRY domain is found in Ran binding protein M (RanBPM, also known as RanBP9) and RanBP10. RanBPM and RanBP10 arenon-canonical members of the Ran binding protein family that lack the Ran binding domain and do not associate with Ran GTPase in vivo. RanBPM is a scaffolding protein important for a variety of cellular processes [, ]. RanBP10 has been shown to function as a cytosolic guanine exchange factor and microtubule regulator [, ]. Both of these proteins contain a SPRY domain, which has been implicated in mediating protein-protein interactions with a variety of targets, including the DEAD-box containing ATP-dependent RNA helicase (DDX-4) [, , ].
