The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is usually found N-terminal to a Myb-like DNA-binding domain and a GATA-binding domain. In some instances, ELM2 is instead found associated with the ARID DNA-binding domain . This suggests that ELM2 may itself be involved in DNA binding or may function as a protein-protein interaction domain.This domain is found in a variety of proteins, including:Mesoderm induction early response protein 1: a transcriptional repressor regulating the expression of a number of genes, including SP1 target genes. It probably functions through the recruitment of HDAC1, a histone deacetylase involved in chromatin silencing [].REST corepressor 2: may act as a component of a corepressor complex that represses transcription.Metastasis-associated protein MTA1: a component of the histone deacetylase NuRD complex, which participates in the remodelling of chromatin [].Arginine-glutamic acid dipeptide repeats protein (RERE): acts as a transcriptional repressor during development and may play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus, particularly to PML oncogenic domains (PODs), and triggers caspase-3 activation, leading to cell death [].
