Reticulophagy receptor 1, previously known as FAM134B, is essential for ER homeostasis. It is a endoplasmic reticulum (ER) resident receptor that binds to autophagy modifiers LC3 and GABARAP, and facilitates ER degradation by autophagy. It may promote membrane remodelling and ER scission via the membrane-bending capacity of its reticulon domain, whereas its LIR motif may be necessary to target the ER fragments to autophagosomes for lysosomal degradation [].
