The repulsive guidance molecule (RGM) family consists of bone morphogenetic protein (BMP) coreceptors RGMA, DRAGON (RGMB), and hemojuvelin (RGMC). RGMs are a class of GPI-anchored glycoproteins that signal via the neogenin and the BMP pathways [, ].RGMA binds its receptor neogenin and is also a BMP co-receptor []. In addition to controlling axon guidance, the binding of RMGA to neogenin regulates neuronal death and cell differentiation in the developing brain [, ]and inhibits mammalian CNS neurite outgrowth after injury []. RGMA plays a role in multiple sclerosis [].
