The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression []. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins []. Ripply2.2 is also known as Bowline and is an associate protein of the transcriptional co-repressor XGrg-4 []. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homologue [].
