RNF126 is a Bag6-dependent E3 ubiquitin ligase that is involved in the mislocalized protein (MLP) pathway of quality control []. It regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR) []. Moreover, RNF126 promotes cancer cell proliferation by targeting the tumour suppressor p21 for ubiquitin-mediated degradation, and could be a novel therapeutic target in breast and prostate cancers []. It is also able to ubiquitinate cytidine deaminase (AID), a poorly soluble protein that is essential for antibody diversification []. In addition, RNF126 and the related protein, RNF115 associate with the epidermal growth factor receptor (EGFR) and promote ubiquitination of EGFR, suggesting they play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors []. RNF126 contains an N-terminal BCA2 zinc-finger domain (BZF), the AKT-phosphorylation sites, and the C-terminalC3H2C3-type RING-H2 finger.This entry represents the C3H2C3-type RING-H2 finger.
RNF126 is a Bag6-dependent E3 ubiquitin ligase that is involved in the mislocalized protein (MLP) pathway of quality control []. It regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR) []. Moreover, RNF126 promotes cancer cell proliferation by targeting the tumour suppressor p21 for ubiquitin-mediated degradation, and could be a novel therapeutic target in breast and prostate cancers []. It is also able to ubiquitinate cytidine deaminase (AID), a poorly soluble protein that is essential for antibody diversification []. In addition, RNF126 and the related protein, RNF115 associate with the epidermal growth factor receptor (EGFR) and promote ubiquitination of EGFR, suggesting they play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors []. RNF126 contains an N-terminal BCA2 zinc-finger domain (BZF), the AKT-phosphorylation sites, and the C-terminal C3H2C3-type RING-H2 finger.
