RPL14 is a component of the large ribosomal subunit in both archaea and eukaryotes with KOW motif at its N terminus []. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4 []. Although RPL14 is well conserved, it is not found in all archaea, and therefore it is presumably not essential [].
L14 is an eukaryote-specific ribosomal protein from the 60S ribosomal subunit, which is conserved in some but not all archaea. In yeast, L14 assembles in the nucleolus at an early stage into pre-60S particles []. Auto-antibodies to RPL14 in humans have been associated with systemic lupus erythematosus [].
