This is a domain found in a group of retrotransposon-derived proteins from animals, including PEG10, RTL1 and retrotransposon Gag-like 3/5/6. PEG10 binds its own mRNA and self-assembles into virion-like capsids [, ]. RTL1 plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta []. RTL3 plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal []. This entry represents the C-terminal capsid-like domain.
This entry represents the protease (PRO) domain of eukaryotic retrotransposon-derived proteins from the Mart family, RTL1 and PEG10 []. Mammal RTL1 plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. PEG10 is a retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids that are released from cells, enabling intercellular transfer of PEG10 mRNA [].
This domain is found in some members of the Mart (mammalian retrotransposon-derived) family, including LDOC1/Mart7, LDOC1L/Mart6, RTL1/Mart1, RTL3-8 [, ]. LDOC1 is a MZF-1-interacting protein, inhibits NF-kappaB activation and relates with cancer and some other diseases [, , , ]. LDOC1 is a small protein and this entry covers almost its full length. In RTL proteins, it represents the N-terminal capsid-like domain. RTL1 plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta []. RTL3 plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal [].
