RWDD3, also known as RSUME, is a RWD-containing protein that enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favours sumoylation of specific targets. It also increases IkappaB levels and stabilizes HIF-1alpha during hypoxia, leading to inhibition of NF-kappaB and increased HIF-1 transcriptional activity [, ].
