S100A10 (also known as p11) belongs to the S100 calcium-binding family and is involved in intracellular trafficking and cell migration []. S100A10 may be involved in the promotion of cancer cell invasion and migration []. S100A10 is required for the activity of Rac1, which regulates actin dynamics and promotes cell spreading []. S100A10 forms a heterotetrameric complex with ANX2 (membrane-binding protein annexin A2), which is involved in membrane transport events such as endocytosis and exocytosis []. ANX2 can also bind and bundle actin filaments and is required for actin dynamics to promote cell migration and spreading [].
