This domain is found three times in human Sacsin (SACS) and similar proteins mainly found in eukaryotes. SACS is a co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins []. This domain is also found once in Protein NO VEIN from Arabidopsis thaliana (Nov), which is required for cell fate determination during embryogenesis []and mediates auxin-dependent coordinated cell-fate specification and patterning in embryos, shoots and roots [, ].
