This entry represents the protein strawberry notch homologue 2 (SBNO2) from vertebrates. It may be a component of the pathways that contribute to the downstream anti-inflammatory effects of IL-10 []. The genetic variations in the SBNO2 gene have been linked to susceptibility to Crohn's disease, a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus [].Strawberry notch proteins carry DExD/H-box groups and helicase C-terminal domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes []. Strawberry notch was first identified in Drosophila where functions downstream of Notch and regulates gene expression during development [, ].
