This family consists of secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2) []. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma [, , ]. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation []. It is also involved in lung development [].
