The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing [].
The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing [].
SCML2 is a mammalian Polycomb-group protein, which associates with the Polycomb repressive complex-1 (PRC1) that is essential for the epigenetic regulation of gene expression. Isoform SCML2A has been shown to bind to PRC1 via its SPM domain and to interact with ncRNAs through a novel RNA-binding region (RBR). The RBR is necessary for targeting of SCML2A to chromatin and PRC1 recruitment, suggesting a role for ncRNAs in regulating SCML2 function [].This entry represents the RNA-binding region of SCML2, also found in other Polycomb-group proteins.
