Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains [].This entry represents Serinc1 (also known as TDE1L or TDE2) and Serinc3 (also known as TDE1). Rat Serinc1 co-localises with lipid biosynthetic enzymes in endoplasmic reticulum membranes. Its two functions, serine synthesis and membrane incorporation, are linked to each other [].Serinc3 expression is increased in some tumours [, ].
Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains []. In the rat brain, expression of Serinc1 and Serinc2 mRNA is up-regulated by induced seizures, whereas Seric5 is down-regulated, indicating a novel mechanism linking neural activity and lipid biosynthesis.This entry represents Serinc2.
Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains []. In the rat brain, expression of Serinc1 and Serinc2 mRNA is up-regulated by induced seizures, whereas Seric5 is down-regulated, indicating a novel mechanism linking neural activity and lipid biosynthesis.This entry represents Serinc5 (also known as Tpo1). It may play a role in myelin formation [].
