Scm-like-4MBT1 and Scm-like-4MBT2 are structurally related to the transcriptional repressor Polycomb group (PcG) proteins. They contain a SAM domain, a SLED domain [], and four MBT repeats []. The MBT repeats of the human SFMBT1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails []. SFMBT1 also forms a stable complex with LSD1 and CoREST that causes chromatin compaction and transcriptional repression of target genes, including those encoding replication-dependent histones [].This entry represents the SAM domain of Scm-like-4MBT1/2.
