SH2B adapter protein 2 (SH2B2, also known as APS) belongs to the SH2B family of adapter proteins []. SH2B2 is involved in multiple signalling pathways, includingcytokine signalling and insulin receptor signalling [, ]. It also binds to Vav3, a member of the vav proto-oncogene family, and increases its activity [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
This entry represents the SH2 domain of SH2B2.SH2B adapter protein 2 (SH2B2, also known as APS) belongs to the SH2B family of adapter proteins []. SH2B2 is involved in multiple signalling pathways, including cytokine signalling and insulin receptor signalling [, ]. It also binds to Vav3, a member of the vav proto-oncogene family, and increases its activity [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
