This entry includes the single SH2 domain of SH2D2A. SH2D2A interacts with and modulates Lck activity [].In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
