SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation []. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains.
SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation []. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains. This entry represents the second SH3 domain of SH3RF2.
SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation []. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains. This entry represents the first SH3 domain, located at the N-terminal half, of SH3RF2.
