SLC7A6OS share protein sequence similarity with budding yeast Iwr1, which binds RNA pol II and regulates the transcription of specific genes. Danio rerio SLC7A6OS plays a role in defined areas of the developing central nervous system [].
Iwr1 is involved in transcription from polymerase II promoters; it interacts with with most of the polymerase II subunits []. Deletion of this protein results in hypersensitivity to the K1 killer toxin []. This entry represents a domain found in Iwr1. This domain can also be found in SLC7A6OS and RDM4 (At2g30280). RDM4 is a regulatory factor for several RNA polymerases [].
