Secreted Ly-6/uPAR-related protein 1 (SLURP-1) belongs to the Ly-6/uPAR superfamily of receptor and secreted proteins. SLURP1 has antitumor activity. It was found to be a marker of late differentiation of the skin. SLURP1 is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin [, , ]. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterised by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens) [, ].
