The SIAMESE-RELATED (SMR) family of cyclin-dependent kinase (CDK) inhibitors is a plant-specific family that consist of SIAMESE (SIM) and related proteins []. SIM controls endoreplication during trichome development []. SMR2 acts to restrict cell proliferation during leaf growth in Arabidopsis and SIM, SMR1/LGO, and SMR2 play overlapping roles in controlling the transition from cell division to endoreplication [].
