This entry represents the SET domain of SET and MYND domain-containing protein 4 (SMYD4). SMYD4 functions as a potential tumour suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha []. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ].
